Protein engineering of novel biologics is at the heart of a wide variety of advancements in research, medicine, industry, health, and biotechnology. Understanding and improving upon enzymatic properties like stability and catalytic activity as well as immunologically relevant proteins like cytokines has led to new therapeutics like enzyme replacement for genetic disorders and modified growth factors for immunology and oncology. Protein engineering has also proved important for commercially exciting advances in the food industry like the meatless Impossible Burger or biotechnology for further optimizing on the enzymes once collected from extremophile microorganisms for use in molecular biology.
Both protein engineering strategies, rational design or directed evolution, have benefited from the rise of synthetic biology tools like gene library synthesis and high-throughput screening assays. Regardless of whether research starts with rational, structure-based gene design or with mutagenesis libraries and screening for directed evolution, library synthesis and rapid screening are consistently time and resource bottlenecks. High-throughput solutions on the BioXp 3200 System increase turnaround time and provide the ability to rapidly iterate beyond what was previously possible.